Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same

US6221907A · kind A · utility

Assignee

• Hoechst Marion Roussel · FR

Inventors

• Serge Bernard · Mitry-Mory, FR
• Denis Carniato · Marcoussis, FR
• Jean-Francois Gourvest · Claye-Souilly, FR
• Jean-Georges Teutsch · Pantin, FR
• Jochen Knolle · Kriftel, DE
• Hans Ulrich Stilz · Frankfurt am Main, DE
• Volkmar Wehner · Bischofsheim a.d.Rhön, DE
• Sarah C. Bodary · San Francisco, US
• Thomas Gadek · Oakland, US
• Robert McDowell · San Francisco, US
• Robert Pitti · Corona, US

Key dates

• Filing date: Feb 2, 1999
• Grant date: Apr 24, 2001
• Expiry date: Feb 2, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The subject of the invention is the products of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and G are as defined in the description, the dotted lines represent an optional second bond, as well as the addition salts with acids and bases and the esters, their preparation process and the intermediates of this process, their use as medicines and the pharmaceutical compositions containing them.