Patent · US Expired

Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides

US6221958A · kind A · utility

80Cited by

10References

42Claims

0Family size

Assignees

Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR
Poly-Med, Inc. · US

Inventors

Shalaby W. Shalaby · Anderson, US
Steven A. Jackson · Newton, US
Jacques-Pierre Moreau · Upton, US

Key dates

Filing date	Jan 26, 1999
Grant date	Apr 24, 2001
Priority date	—
Expiry date	Jan 26, 2019

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.