Isolated nonapeptides presented by HLA molecules, and uses thereof

US6222012A · kind A · utility

Assignee

• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

• Thierry Boon-Falleur · Brussels, BE
• Pierre van der Bruggen · Brussels, BE
• Etienne De Plaen · Brussels, BE
• Christoph Lurquin · Brussels, BE
• Catia Traversari · Milano, IT
• Beatrice Gaugler · Brussels, BE
• Benoit Van den Eynde · Brussels, BE
• Pedro Romero · Rio de Janeiro, BR

Key dates

• Filing date: Feb 23, 1995
• Grant date: Apr 24, 2001
• Expiry date: Feb 23, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention involves nonapeptides bound by HLA molecules such as HLA-A1. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.