[1,2,4] triazolo [1,5-C] pyrimidine derivatives
US6222035A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 23, 1999 |
| Grant date | Apr 24, 2001 |
| Priority date | — |
| Expiry date | Sep 23, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
[1,2,4]Triazolo[1,5-c]pyrimidine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof are provided, which have adenosine A.sub.2A receptor antagonism and are useful for the treatment or prevention of various diseases induced by hyperactivity of adenosine A.sub.2A receptors (for example, Parkinson's disease or senile dementia): ##STR1## wherein R.sup.1 represents substituted or unsubstituted aryl, or the like; R.sup.2 represents hydrogen, halogen, lower alkyl, substituted or unsubstituted aryl, or the like; R.sup.3 represents hydrogen, halogen, XR.sup.10 (wherein X represents O or S; and R.sup.10 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic ring, substituted or unsubstituted aralkyl, lower alkyl, or hydroxy lower alkyl), or the like; and Q represents hydrogen or 3,4-dimethoxybenzyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.