Method of making .alpha.-chloro-.alpha.,.alpha.-difluoro aromatic compounds
US6222078A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 10, 1998 |
| Grant date | Apr 24, 2001 |
| Priority date | — |
| Expiry date | Dec 10, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C22/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a method of making an .alpha.-chloro-.alpha.,.alpha.-difluoro aromatic compound. An .alpha.,.alpha.,.alpha.-trichloro aromatic compound having the general formula ##STR1## where Y is C or N, R is halogen, R', amino, NHR', NR'.sub.2, OR', OCF.sub.3, or nitro, R' is alkyl from C.sub.1 to C.sub.10, n is 1, 2, or 3, and m is 0 to 5, is reacted with about 0.7 to about 1.4 equivalents of hydrogen fluoride per chlorine to be replaced, in the presence of about 0.001 to about 1.5 wt %, based on wt % of said .alpha.,.alpha.,.alpha.-trichloro aromatic compound, of a catalyst selected from the group consisting of oxides of Ti, Zr, V, Nb, Ta, Mn, Re, Fe, Ru, Os, Al, Ga, In, Ge, Sn, Sb, and Bi, MoO.sub.q X.sub.r, (M).sub.p Mo.sub.s+t O.sub.3s+4t, (M).sub.p VO.sub.3, (M).sub.p VO.sub.5, WO.sub.q X.sub.r, (M).sub.p W.sub.s+t O.sub.3s+4t, and mixtures thereof, where M is a cation, X is amine, phosphine, carboxylate, or ketone, p is the negative of the valence of the anion times the inverse of the valence of M, q is 0 to 3, r is 0 to 6, and s is 0 to 4, and t is 1 to 5. Yields of 80% or more were obtained.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.