Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US6224912A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 9, 1998 |
| Grant date | May 1, 2001 |
| Priority date | — |
| Expiry date | Nov 9, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N11/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A material for suppressing proliferation of cancer cells is produced by entrapping cancer cells in a selectively-permeable structure such as a bead, and culturing the entrapped cells in a culture medium. Entrapment restricts growth of the cancel cells during culturing and causes the cells to produce in the culture medium a material having a molecular weight of at least about 30 kd that suppresses proliferation of cancer cells. The material is separated from the culture medium by filtering the medium through a filter that separates material having a molecular weight of at least about 30 kd from material having a molecular weight of less than 30 kd. The structure that entraps the cells may contain 10,000 to 500,000 cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.