Method of detecting solid cancer cells and tissue atypia and method of testing tissues for use in bone marrow transplantation and peripheral blood stem cell transplantation
US6225051A · kind A · utility
66Cited by
1References
7Claims
0Family size
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Key dates
| Filing date | Jun 26, 1998 |
| Grant date | May 1, 2001 |
| Priority date | — |
| Expiry date | Jun 26, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides a method of detecting solid cancer cells which comprises determining the level of expression of WT1 gene in a test tissue, a method of detecting the atypia of a tissue which comprises determining the level of expression of WT1 gene in the tissue, and a method of testing a graft material tissue for bone marrow or peripheral blood stem cell transplantation which comprises determining the level of expression of WT1 gene in a CD34.sup.- cell fraction of the tissue to detect leukemic cells and solid cancer cells in the tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.