Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma
US6225070A · kind A · utility
8Cited by
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18Claims
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Assignee
Inventors
Key dates
| Filing date | Aug 7, 1997 |
| Grant date | May 1, 2001 |
| Priority date | — |
| Expiry date | Aug 7, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/323
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to monoclonal antibodies which differentially bind oxidation-specific epitopes on lipoprotein in blood, arterial tissue and vascular tissue, including atherosclerotic plaque formed in arterial tissue and vascular tissue through lipoprotein oxidation. Methods for use of the antibodies in detecting and monitoring lipoprotein oxidation in vivo and in vitro are described, as are methods for inhibiting lipoprotein oxidation in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.