Myelin basic protein MRNA transport and translation enhancer sequences
US6225082A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 9, 1997 |
| Grant date | May 1, 2001 |
| Priority date | — |
| Expiry date | May 9, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/105
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides isolated nucleic acid molecules which comprise sequences from the 3' UTR of myelin basic protein (MBP) mRNA. The subject isolated nucleic acid molecules confer properties such as localization, transport and increased translational efficiency of a heterologous mRNA transcript when transcribed into such mRNA. The present invention also provides vectors comprising the subject isolated nucleic acids. The vectors are useful for increasing translational efficiency of mRNA transcripts produced by a heterologous gene incorporated therein. Also provided by the present invention are methods for increasing translation of a heterologous gene. The methods comprise transforming a eukaryotic cell with at least one of the subject vectors having coding sequence for a heterologous gene. Methods for enhancing gene therapy are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.