Enzymatic process for the preparation of (S)-cyanohydrins

US6225095A · kind A · utility

Assignee

• DSM Fine Chemicals Austria GmbH · AU

Inventors

• Peter Pochlauer · Dordrecht, NL
• Michael Schmidt · Weiterstadt, DE
• Irma Wirth · Ansfelden, AT
• Rudolf Neuhofer · Mittertreffling, AT
• Antonia Zabelinskaja-Mackova · Borculo, NL
• Herfried Griengl · Graz, AT
• Cor Van den Broek · Landgraaf, NL
• Raf Reintjens · Etten-Leur, NL
• Herman Jelle Wories · Eijsden, NL

Key dates

• Filing date: Dec 29, 1998
• Grant date: May 1, 2001
• Expiry date: Dec 29, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/88
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Process for the preparation of the (S)-enantiomers of optically active cyanohydrins, in which a reaction mixture of PA1 a) an aldehyde or ketone dissolved in an organic, water-immiscible or slightly miscible diluent, PA1 b) an aqueous (S)-hydroxynitrile lyase solution and PA1 c) a cyanide group donor is stirred in such a way that an emulsion is formed which is maintained up to the end of the reaction by stirring.