Somatostatin peptides

US6225284A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Rainer Albert · Basel, CH
• Wilfried Bauer · Lampenberg, CH
• Christian Bruns · Glückstadt, DE
• Nagarajan Chandramouli · Morristown, US
• Ian Lewis · Riehen, CH
• Gisbert Weckbecker · Biel-Benken, CH

Key dates

• Filing date: Dec 29, 1997
• Grant date: May 1, 2001
• Expiry date: Dec 29, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Somatostain analogues comprising the amino acid sequence of the formula (I): -(D/L)Trp-Lys-X.sub.1 -X.sub.2, wherein X.sub.1 is a substituted Thr, Ser, Tyr, Glu or Cys residue and X.sub.2 is an .alpha.-amino acid having an aromatic residue on the C.sub..alpha. side chain, or an amino acid unit selected from Dab, Dpr, Dpm, His (Bzl)HyPro, thienyl-Ala, cyclohexyl-Ala and t.-butyl-Ala, the residue Lys of said sequence corresponding to the residue Lys.sup.9 of the native somatostatin-14, in free form, in salt form or complexed with a detectable element have interesting pharmacological properties.