Activated iododerivatives for the treatment of cancer and AIDS
US6225323A · kind A · utility
8Cited by
3References
8Claims
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Key dates
| Filing date | Aug 11, 1998 |
| Grant date | May 1, 2001 |
| Priority date | — |
| Expiry date | Aug 11, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preventing cancer cell and virus replication is through inhibition of the binding of transcription factors to zinc finger binding domains. The compounds are effective in inhibiting growth of a variety of human and animal tumor and leukemia cell lines at low concentrations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.