Azahexane derivatives as substrate isosters of retroviral asparate proteases
US6225345A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 21, 1998 |
| Grant date | May 1, 2001 |
| Priority date | — |
| Expiry date | May 21, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to compounds of formula (I): ##STR1## wherein R.sub.1 and R.sub.10 are each independently of the other lower alkoxycarbonyl; either R.sub.2, R.sub.3 and R.sub.4 are each independently of the other C.sub.1 -C.sub.4 alkyl and R.sub.7, R.sub.8 and R.sub.9 are each selected from hydrogen and C.sub.1 -C.sub.4 alkyl, with not more than 2 of the radicals being hydrogen; or R.sub.7, R.sub.8 and R.sub.9 are each independently of the other C.sub.1 -C.sub.4 alkyl and R.sub.2, R.sub.3 and R.sub.4 are each selected from hydrogen and C.sub.1 -C.sub.4 alkyl, with 1 or 2 of the radicals being hydrogen; R.sub.5 is phenyl or cyclohexyl; and R.sub.6 is phenyl or cyanophenyl; or salts thereof; those compounds are inhibitors of retroviral aspartate proteases and are effective, for example, against HIV.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.