Chromosome 11-linked coronary heart disease susceptibility gene CHD1

US6225451A · kind A · utility

Assignee

• Myriad Genetics, Inc. · US

Inventors

• Dennis Ballinger · Menlo Park, US
• Wei Ding · Salt Lake City, US
• Susanne Wagner · Mittenwalde, DE
• Mark Hess · Cincinnati, US

Key dates

• Filing date: Mar 4, 1999
• Grant date: May 1, 2001
• Expiry date: Mar 4, 2019

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/324
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Human coronary heart disease susceptibility gene (CHD1), some alleles of which are related to susceptibility to coronary heart disease. Germline mutations in the CHD1 gene and their use in the diagnosis of predisposition to coronary heart disease and to metabolic disorders, including hypoalphalipoproteinemia, familial combined hyperlipidemia, insulin resistant syndrome X or multiple metabolic disorder, obesity, diabetes and dyslipidemic hypertension. Presymptomatic therapy of individuals who carry deleterious alleles of the CHD1 gene (including gene therapy, protein replacement therapy, and administration of protein mimetics and inhibitors). The screening of drugs for dyslipidemic therapy.