Sustained-release microgranules containing Diltiazem as the active principle

US6228395A · kind A · utility

Assignee

• SOCIETE LABORATOIRES DES PRODUITS ETHIQUES ETHYPHARM · FR

Inventors

• Patrice Debregeas · Paris, FR
• Gerard Leduc · Nemours, FR
• Pascal Oury · Le Chesnay, FR
• Pascal Suplie · Montaure, FR

Key dates

• Filing date: Nov 25, 1998
• Grant date: May 8, 2001
• Expiry date: Nov 25, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel forms of sustained-release microgranules (LP) containing diltiazem are disclosed. The microgranules consist of a neutral granular carrier coated with an active layer including diltiazem or a pharmaceutically acceptable salt thereof as the active principle, a surfactant and a binder, and an outer layer providing sustained release of the active principle (layer LP).