Patent · US Expired

Assays for compounds which extend life span

US6228583A · kind A · utility

8Cited by

1References

13Claims

0Family size

Assignee

Massachusetts Institute of Technology · US

Inventors

Leonard Guarente · Sharon, US
David A. Sinclair · Feldkirchen-Westerham, DE

Key dates

Filing date	Jul 31, 1998
Grant date	May 8, 2001
Priority date	—
Expiry date	Jul 31, 2018

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/52
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Methods of identifying agents or compounds which are capable of inhibiting the replication and/or accumulation of DNA circles in cells are described. Also described are methods of assessing the ability of a compound to extend life span, as well as methods of extending life span, comprising administering to a cell a compound identified by the assays described herein which extends life span. The invention also pertains to isolated mWRN, or an active derivative or fragment thereof and to an isolated nucleic acid molecule which encodes mWRN, or an active derivative or fragment thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.