Plasmids encoding immunogenic proteins and intracellular targeting sequences

US6228621A · kind A · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• William V. Williams · Havertown, US
• Michael Madaio · Via Enrico Fermi, US
• David B. Weiner · Yeadon, US

Key dates

• Filing date: Oct 23, 1997
• Grant date: May 8, 2001
• Expiry date: Oct 23, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Improved vaccines are disclosed. The improved vaccines include a nucleotide sequence that encodes a coding sequence that comprises an immunogenic target protein linked to or comprising an intracellular cellular targeting sequence, the coding sequence being operably linked to regulatory elements are disclosed. Methods of immunizing individuals are disclosed.