Purine derivatives having phosphodiesterase IV inhibition activity

US6228859A · kind A · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• David Cavalla · Cambridge, GB
• Mark Chasin · Manalapan, US
• Peter Hofer · Liestal, CH
• Andre Gehrig · Basel, CH
• Peter Wintergerst · Basel, CH

Key dates

• Filing date: Dec 11, 1998
• Grant date: May 8, 2001
• Expiry date: Dec 11, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of the formula (I): ##STR1## wherein R.sup.3 is selected from the group consisting of C.sub.1-10 alkyl, C.sub.1-10 alkenyl, C.sub.3-10 cycloalkyl, C.sub.4-10 cycloalkylalkyl or C.sub.3-10 cycloalkenyl, wherein said alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or cycloalkenyl is optionally substituted in one position with hydroxy; or benzyl, wherein said benzyl is optionally substituted in one or two positions with halogen, alkoxy, cycloalkoxy or polycycloalkyl, and wherein said alkyl moiety of said alkoxy or cycloalkoxy substituent is optionally substituted in one position with hydroxy; R.sup.8 is selected from the group consisting of hydrogen, C.sub.1-10 alkyl, C.sub.1-10 alkenyl, C.sub.3-10 cycloalkyl, C.sub.4-10 cycloalkylalkyl or C.sub.3-10 cycloalkenyl, wherein said alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or cycloalkenyl is optionally substituted in one position with hydroxy; or benzyl, wherein said benzyl is optionally substituted in one or two positions with halogen, alkoxy, cycloalkoxy or polycycloalkyl, and wherein said alkyl moiety of said alkoxy or cycloalkoxy is optionally substituted in one position with hydroxy; R.sup.6a and R.sup.6b are ind…