Asymmetric epoxides, their synthesis and use
US6228955A · kind A · utility
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25Claims
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Key dates
| Filing date | Oct 20, 1997 |
| Grant date | May 8, 2001 |
| Priority date | — |
| Expiry date | Oct 20, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F283/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing an optically-enriched chiral epoxide of formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each independently selected from H, R, R--CO-- and R--O--CO--, each R independently being substantially a hydrocarbon group of up to 20 carbon atoms, and X is an alkyl or cycloalkyl group of up to 10 carbon atoms, provided that --CO--X is not enolisable, which comprises the asymmetric epoxidation of a corresponding prochiral alkene of formula II EQU R.sup.1 R.sup.2 C.dbd.CR.sup.3 --CO--X (II) by reaction with an oxidant in the presence of a chiral catalyst. Many optically-enriched epoxides (I) are novel.
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