Method for the preparation of citalopram
US6229026A · kind A · utility
29Cited by
1References
27Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 7, 2000 |
| Grant date | May 8, 2001 |
| Priority date | — |
| Expiry date | Jan 7, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C237/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the preparation of citalopram comprising the steps of reacting a compound of Formula (IV) wherein R.sup.1 is C.sub.1-6 alkyl and X is O or NH, successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent of 3-halogen-N,N-dimethylpropylamine, respectively, effecting ring-closure of the resulting compound of Formula (V) wherein R.sup.1 and X are as defined above, and converting the resulting 1,3-dihydroisobenzofuran compound to the corresponding 5-cyano derivative, i.e. citalopram.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.