Arylalkylpiperazine compounds as antioxidants

US6232314A · kind A · utility

Assignee

• MONASH UNIVERSITY · AU

Inventors

• Bevyn Jarrott · Melbourne, AU
• Philip Beart · Ivanhoe, AU
• William Roy Jackson · Melbourne, AU
• Vijaya Kenche · Melbourne, AU
• Alan D. Robertson · Hornsby, AU
• Maree Patricia Collis · Melbourne, AU

Key dates

• Filing date: Mar 18, 1999
• Grant date: May 15, 2001
• Expiry date: Mar 18, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

##STR1## Arylalkylpiperazine compounds (1) wherein B is aryl or optionally substituted aryl; R.sub.1 is hydroxy; R.sub.2 and R.sub.3 are the same or different and are independently selected from hydrogen or C.sub.1-3 alkyl; m is 0, 1 or 2; D is a linking chain of atoms which may be optionally substituted and which contains from 1 to 8 atoms in the chain; E is a phenolic antioxidant group or a corresponding amino derivative thereof wherein the phenolic hydroxyl is replaced by amino, are disclosed. The compounds have both free radical scavenging activity and block excitatory amino acid activity. Some compounds of the present invention also display an affinity for voltage-sensitive sodium channels.