Diagnostic application of sono-chemical excitation of fluorescent photosensitizers
US6233481A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 5, 1998 |
| Grant date | May 15, 2001 |
| Priority date | — |
| Expiry date | Oct 5, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/0017
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a method for generating an image of a selected area of tissue, the method includes steps of: (a) providing a fluorescent photosensitizer compound in combination with a hydrogen-containing solvent to the selected area of tissue; (b) generating acoustic energy for generating free radicals from the solvent; (c) reacting the free radicals with an oxalate ester to generate a key intermediate; (d) transferring chemical energy to the fluorescent photosensitizer compound from the key intermediate; (e) activating the fluorescent photosensitizer compound with the transferred energy to emit long wavelength light; and (f) detecting the long wavelength light to generate the image of the selected area of tissue. In one embodiment the oxalate ester is comprised of ester bis (2,4-dinitrophenyl) oxalate (DNPO). In one application, a selected area of living tissue is analyzed to identify an abnormality within the tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.