Poly(organophosphazene) matrices for bone replacement

US6235061A · kind A · utility

Assignees

• The Penn State Research Foundation · US
• Massachusetts Institute of Technology · US

Inventors

• Cato T. Laurencin · Philadelphia, US
• Saadiq El-Amin · Watertown, US
• Archel M. A. Ambrosio · Philadelphia, US
• Shawn R. Pucher · San Diego, US
• Harry R. Allcock · State College, US

Key dates

• Filing date: Apr 4, 1994
• Grant date: May 22, 2001
• Expiry date: Apr 4, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A highly porous three-dimensional biodegradable poly(organophosphazene) matrix with hydrolytically unstable side chains is prepared and used as a scaffold for the growth of osteoblast cells. In a preferred embodiment, the poly(organophosphazene) includes between 10 and 90% hydrolytically unstable side chains including glucosyl, glyceryl, glyceryl, imidazolyl or ethoxy units, for example, poly[(methylphenoxy)(ethyl glycinato) phosphazene]. The addition of the glucosyl, glycinyl or glyceryl side chains to the polymer can also be used generally to enhance growth rates of cells adhered to the polymer, presumably through uptake and metabolism of the simple sugar or alcohol units.