Method for manufacturing fluoroaryl magnesium halide
US6235222A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 22, 1999 |
| Grant date | May 22, 2001 |
| Priority date | — |
| Expiry date | Oct 22, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/027
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In order to provide a method of safely, efficiently, and industrially manufacturing fluoroaryl magnesium halide containing no impurities, such as coloring components, by a relatively gradual reaction compared with the conventional reactions, and a method of readily and efficiently manufacturing a highly-pure fluoroaryl borane derivative, fluoroaryl magnesium halide expressed by General Formula (1): ##STR1## PA1 where each of R.sub.1 -R.sub.5 independently represents H, F, a hydrocarbon group, or an alkoxy group, provided that at least three of R.sub.1 -R.sub.5 are fluorine atoms, and X.sub.a represents Cl, Br, or I; PA1 is manufactured by reacting, in a solvent containing a chain ether solvent, hydrocarbon magnesium halide expressed by General Formula (2): EQU R.sub.6 MgX.sub.a (2) PA1 where R.sub.6 represents a hydrocarbon group, and X.sub.a represents Cl, Br, or I; PA1 with fluoroaryl halide expressed by General Formula (3): ##STR2## PA1 where each of R.sub.1 -R.sub.5 independently represents H, F, a hydrocarbon group, or an alkoxy group, provided that at least three of R.sub.1 -R.sub.5 are fluorine atoms and X.sub.b represents Br or I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.