Nucleic acid constructs containing genes encoding transport signals

US6235526A · kind A · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Hans-Harald Sedlacek · Marburg, DE
• Rolf Mueller · Ingolstadt, DE
• Reinhard Luehrmann · Marburg, DE

Key dates

• Filing date: May 2, 1997
• Grant date: May 22, 2001
• Expiry date: May 2, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2840/20
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Nucleic acid constructs are disclosed which possess a nuclear retention signal which is linked, downstream in the reading direction, to a transgene. The nuclear retention signal can regulate the presence of the transcription product in the cell nucleus or else the intracellular transport of the transcription product.