Anticoagulant peptidyl-arginine aldehyde derivatives
US6235707A · kind A · utility
1Cited by
0References
7Claims
0Family size
Assignee
Inventors
- Sandor Bajusz
- Attila Juhasz
- Eva Barabas
- Andras Feher
- Gabriella Szabo
- Erzsebet Szell nee Hasenohrl
- Iren Veghelyi nee Fauszt
- Emilia Lavich nee Oszko
- Eva Kaszas
- Jozsef Lango
- Imre Moravcsik
- Agnes Szeker nee Peszeky
- Zsuzsanna Taschler nee Pasztor
- Gabor Toth
- Zsuzsanna Mohai nee Nagy
- Anna Maria Szalkay nee Hollosi
- Klara Makk nee Ocskay
Key dates
| Filing date | Nov 23, 1998 |
| Grant date | May 22, 2001 |
| Priority date | — |
| Expiry date | Nov 23, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new peptidyl-arginine aldehyde compounds of formula (I) EQU Q-D-Xaa-Pro-Arg-H (I) wherein PA1 Q represents an acyl group of formula Q'--OCO, wherein Q' represents an alkyl-group with 1-3 carbon atoms, PA1 D-Xaa represents a 3-cyclobutyl-D-alanyl- or 3-cyclopentyl-D-alanyl group, PA1 Pro represents an L-prolyl group, and PA1 Arg represents an L-arginyl group, and acid-addition salts thereof, and pharmaceutical compositions comprising them, which are suitable for the prevention and cure of thrombosis and accelerated blood clotting.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.