Heparin binding mitogen with homology to epidermal growth factor (EGF)
US6235884A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Sep 22, 1998 |
| Grant date | May 22, 2001 |
| Priority date | — |
| Expiry date | Sep 22, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/22
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are heparin binding mitogens which include an epidermal growth factor-homologous segment (HB-EHM). These factors stimulate proliferation of fibroblast cells, epithelial cells, and smooth muscle cells, but not endothelial cells. Also disclosed are isolated antibodies that recognize, and purified nucleic acids that encode, the above growth factors as well as isolated polypeptides, vectors containing such nucleic acids, and cells harboring such vectors. Growth factors of this invention may be used for accelerating the rate of wound healing, for the in vitro culture of HB-EHM-responsive cells, and for the identification of antagonists to HB-EHM.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.