Rat hedgehog protein-1 (Vhh-1)

US6235885A · kind A · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Thomas M. Jessell · New York, US
• Jane Dodd · New York, US
• Henk Roelink · Seattle, US
• Thomas Edlund · Umeå, SE

Key dates

• Filing date: Nov 27, 1996
• Grant date: May 22, 2001
• Expiry date: Nov 27, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides an isolated nucleic acid molecule encoding a vertebrate Vhh-1 protein. The preferred embodiments are rat and human Vhh-1 protein. This invention provides purified vertebrate Vhh-1 protein and a method to purify same. This invention provides isolated nucleic acid molecules encoding a human and a rat Vhh-1 protein and the purified rat and human Vhh-1 protein encoded by same. This invention provides a vector encoding a vertebrate Vhh-1 protein and mammalian cells comprising such vectors. This invention provides antibodies directed to a vertebrate Vhh-1 protein. This invention further provides nucleic acid probes useful for detecting a nucleic acid molecule encoding a vertebrate Vhh-1 protein. This invention provides pharmaceutical compounds comprising the human Vhh-1 protein. This invention provides nonhuman transgenic animals which express DNA encoding a vertebrate Vhh-1 protein. This invention provides treatments for alleviating abnormalities associated with the vertebrate Vhh-1 protein.