Nuclear receptor ligands and ligand binding domains

US6236946A · kind A · utility

Inventors

• Thomas S. Scanlan · San Francisco, US
• John D. Baxter · West Melbourne, US
• Robert Fletterick · Hillsborough, US
• Richard L. Wagner · San Francisco, US
• Peter J. Kushner · San Francisco, US
• James Apriletti · Berkeley, US
• Brian West · San Francisco, US
• Andrew K. Shiau · San Francisco, US

Key dates

• Filing date: Dec 13, 1996
• Grant date: May 22, 2001
• Expiry date: Dec 13, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2299/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as "TR"). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.