Monolithic matrix for separating bio-organic molecules
US6238565A · kind A · utility
52Cited by
8References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 16, 1998 |
| Grant date | May 29, 2001 |
| Priority date | — |
| Expiry date | Sep 16, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/8827
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention provides monolithic polymer matrices for the separation of bio-organic molecules by liquid chromatography. In one embodiment, the matrix is formed from a polymerization mixture including (i) a hydrophobic monomer, (ii) a crosslinking agent, and (iii) a porogenic solvent or mixture of porogenic components. The monolithic matrices of the invention are particularly useful for resolving polynucleotides (e.g., DNA and/or RNA) in samples by way of reversed-phase ion-pairing chromatography.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.