Process for stabilizing proteins

US6238664A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Klaus Hellerbrand · Moorenweis, DE
• Appollon Papadimitriou · Bichl, DE
• Gerhard Winter · Dossenheim, DE

Key dates

• Filing date: Nov 19, 1998
• Grant date: May 29, 2001
• Expiry date: Nov 19, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/963
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An aqueous protein solution buffered with a potassium phosphate buffer, in which the ratio of potassium ions to sodium ions in the solution is at least 10:1, is resistant to the formation of protein aggregates and particles under conditions of freezing, thawing, lyophilization, and reconstitution.