Monoclonal antibodies directed against the microtubule-associated protein tau

US6238892A · kind A · utility

Assignee

• N.V. Innogenetics S.A. · BE

Inventors

• Marc Mercken · Turnhout, BE
• Eva-Maria Mandelkow · Hamburg, DE
• Marc Vandermeeren · Geel, BE
• Eugeen Vanmechelen · Zevergem, BE
• Andre Van De Voorde · Lokeren, BE

Key dates

• Filing date: Mar 15, 1996
• Grant date: May 29, 2001
• Expiry date: Mar 15, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/975
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau protein. The tau protein ca be obtained from a brain homogenate, itself isolated from the cerebral cortex of a patient having Alzheimer's disease.