Continuous process for producing 2-keto-L-gulonic acid
US6238897A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 13, 1999 |
| Grant date | May 29, 2001 |
| Priority date | — |
| Expiry date | Jul 13, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for the continuous production of 2-keto-L-gulonic acid or a salt thereof from D-sorbitol by fermentation with microorganisms in a nutrient medium containing D-sorbitol that is incubated in a first fermentation vessel with a microorganism capable of converting D-sorbitol to L-sorbose, whereafter the resulting fermentation broth containing L-sorbose is transferred to a second fermentation vessel where it is incubated with a microorganism capable of converting L-sorbose to 2-keto-L-gulonic acid. In a particularly preferred embodiment of this process, the fermentation broth from the first fermentation vessel is sterilized before being transferred to the second fermentation vessel. 2-keto-L-gulonic acid is a valuable intermediate for the production of vitamin C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.