Azetidinone derivatives for the treatment of HCMV infections
US6239125A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 1998 |
| Grant date | May 29, 2001 |
| Priority date | — |
| Expiry date | Oct 6, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D205/09
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound of formula 1: ##STR1## wherein Y is S or O; PA1 R.sub.1 is C.sub.1-6 alkyl; (C.sub.0-6 alkyl)aryl; (C.sub.0-6 alkyl)Het; or PA1 R.sub.1 is an amino acid analog or dipeptide analog of the formula: ##STR2## wherein R.sub.2 is H, C.sub.1-10 alkyl; or an amide or ester group; PA1 A is C.sub.6-10 aryl, Het or CH--R.sub.3 wherein R.sub.3 is C.sub.1-6 alkyl or (C.sub.0-4 alkyl)aryl; and PA1 Z is H, C.sub.1-6 alkyl, or an acyl; PA1 R.sub.4 is hydrogen, lower alkyl, methoxy, ethoxy, or benzyloxy; and PA1 R.sub.5 is alkyl, cycloalkyl, carboxyl group; an aryl; PA1 Het or Het(lower alkyl); or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with phenyl or C(O)OCH.sub.2 -phenyl, said phenyl ring optionally mono- or PA1 di-substituted with among others C(O)OR.sub.7 wherein R.sub.7 is lower alkyl or phenyl(lower alkyl); or a therapeutically acceptable acid addition salt thereof which compounds are useful in the treatment of HCMV infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.