Compounds useful for inhibition of farnesyl protein transferase
US6239140A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 15, 1998 |
| Grant date | May 29, 2001 |
| Priority date | — |
| Expiry date | Jun 15, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds of the formula: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: PA1 a represents N or NO.sup.- ; PA1 R.sup.1 and R.sup.3 are the same or different and each represents halo; PA1 R.sup.2 and R.sup.4 are the same or different and each is selected from H and halo, provided that at least one of R.sup.2 and R.sup.4 is H; PA1 T is a substituent selected from SO.sub.2 R or: ##STR2## PA1 Z is O or S; PA1 n is zero or an integer from 1 to 6; PA1 R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R.sup.5).sub.2 ; PA1 R.sup.5 is H, alkyl, aryl, heteroaryl or cycloalkyl. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.