Low molecular weight displacers for protein purification in hydrophobic interaction and reversed phase chromatographic systems
US6239262A · kind A · utility
8Cited by
5References
31Claims
0Family size
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Key dates
| Filing date | Dec 30, 1998 |
| Grant date | May 29, 2001 |
| Priority date | — |
| Expiry date | Dec 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/76
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for purification of proteins by displacement chromatography in hydrophobic interaction and reversed phase chromatographic systems uses low molecular weight (less than about 10,000) surface-active compounds as displacers. Examples of effective displacers are benzethonium chloride, benzyltributylammonium chloride, and tetrahexylammonium chloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.