Cephem derivatives
US6242437A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1999 |
| Grant date | Jun 5, 2001 |
| Priority date | — |
| Expiry date | Jun 7, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound represented by the following formula (I) is disclosed. This compound has potent antimicrobial activity against a wide spectrum of bacteria from Gram-positive bacteria to Grame-negative bacteria including .beta.-lactamase producing bacteria. In particular, it has higher antimicrobial activity against methicilline-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and imipenem-resistant Pseudomonas aeruginosa than the existing onium salt type cephem derivatives and hence is very useful as a therapeutic agent for infectious diseases derived from various pathogenic bacteria. ##STR1## wherein X represents CH or N, R.sup.1 represents a hydrogen atom, substituted or unsubstituted C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, or cycloalkyl; any one of R.sup.2, R.sup.3, R.sup.4, and R.sup.5 represents R.sup.6 R.sup.7 NSO.sub.2 NH--C.sub.1-6 alkyl where R.sup.6 and R.sup.7, which may be the same or different, represent a hydrogen atom or C.sub.1-6 alkyl; and n is 0 or 1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.