1,2,4-benzothiadiazine derivatives, their preparation and use

US6242443A · kind A · utility

Assignee

• Novo Nordisk A/S · DK

Inventors

• Bernard Pirotte · Liège, BE
• Philippe Lebrun · Vieusart, BE
• Pascal De Tullio · Jupille, BE
• Fabian Somers · Liège, BE
• Jacques Delarge · Dolembreux, BE
• John Bondo Hansen · Avenue Madeleine, DK
• Flemming E. Nielsen · Avenue Madeleine, DK
• Holger Claus Hansen · Frederikssund, DK
• John Patrick Mogensen · Avenue Madeleine, DK
• Tina M.o slashed.ller-Tagmose · Farum, DK

Key dates

• Filing date: Jun 17, 1997
• Grant date: Jun 5, 2001
• Expiry date: Jun 17, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

1,2,4-Benzothiadiazine derivatives represented by formula ##STR1## wherein D, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.12, R.sup.13, R.sup.14, R.sup.15 are defined in the description, composition thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.