Preparation of betamethyl carbapenem intermediates
US6242596A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 12, 1994 |
| Grant date | Jun 5, 2001 |
| Priority date | — |
| Expiry date | May 12, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for making a beta methyl carbapenem intermediate is disclosed. A compound of formula I: ##STR1## is contacted in a non-reactive solvent with methyl Meldrum's acid and a base to produce a compound of formula III: ##STR2## Compound III is treated in an aprotic solvent with a scavenging base, an alkali metal halide and a tri-organo silyl protecting compound for nitrogen to produce a compound of formula IV: ##STR3## Compound IV may be reacted with a nucleophile Nu--X in a non-reactive solvent and base, and the mixture acidified to produce a compound of formula V. ##STR4## Compound V may be reacted with mild acid to produce a compound of formula VI. ##STR5##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.