F18-labeled oxa fatty acids and methods of making and using the same
US6245317A · kind A · utility
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3References
8Claims
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Key dates
| Filing date | Apr 6, 2000 |
| Grant date | Jun 12, 2001 |
| Priority date | — |
| Expiry date | Apr 6, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/0402
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Oxygen substitution at the C3 position of .sup.18 F-labeled fatty acids yields a tracer that is specific to mitochondrial metabolism of fatty acids in liver tissue. Most preferably, the invention is embodied in an [.sup.18 F]fluoro-3-oxa-fatty acid having a chain length of between 8 to 20 carbon atoms. The .sup.18 F-labeled 3-oxa fatty acids of this invention find particular utility the radiolabelling of mammalian liver tissue purposes of positron emission tomography.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.