Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
US6245358A · kind A · utility
2Cited by
9References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 28, 1992 |
| Grant date | Jun 12, 2001 |
| Priority date | — |
| Expiry date | Dec 28, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A lyophilized composition comprising (a) a conjugate comprising a N-alkyl methacrylamide-based copolymer and an anthracycline glycoside linked through a peptide spacer to the copolymer and (b) a cosolubilizing agent may optionally also contain (c) a filler. Also optionally, a targeting moiety may be linked to the copolymer of the conjugate via a peptide spacer. An injectable solution of the conjugate is obtained by reconstitution of the lyophilized composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.