Process for the preparation of HMG-COA reductase inhibitors
US6245535A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 2, 2000 |
| Grant date | Jun 12, 2001 |
| Priority date | — |
| Expiry date | Feb 2, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/07
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed is a process for producing a compound represented by general formula (II-a): ##STR1## (wherein R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R.sup.2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a): ##STR2## (wherein R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R.sup.2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.