Methods and products for treating pseudomonas infection
US6245735A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 29, 1996 |
| Grant date | Jun 12, 2001 |
| Priority date | — |
| Expiry date | Jul 29, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/875
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and products for upregulating cystic fibrosis transmembrane conductance regulators are provided, including methods and products for the treatment of P. aeruginosa infection. The products include polysaccharides that interact with the cystic fibrosis transmembrane conductance regulator (CFTR). The polysaccharide compositions of the invention may be administered to a subject in order to enhance the uptake of P. aeruginosa into the epithelial cells of the subject. The invention also encompasses compositions comprising a lipopolysaccharide-binding region of a CFTR linked to an anti-Pseudomonal drug and methods of use of such compositions. Compositions and methods for gene therapy are also disclosed. The compositions include polysaccharides that bind to CFTR coupled to a gene delivery vehicle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.