Pharmaceutical preparations for treatment of estrogen deficiency in the central nervous system

US6245756A · kind A · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Vladimir Patchev · Jena, DE
• Michael Oettel · Jena, DE
• Sigfrid Schwarz · Jena, DE
• Ina Thieme · Graitschen, DE
• Wolfgang Roemer · Jena, DE

Key dates

• Filing date: Feb 19, 1999
• Grant date: Jun 12, 2001
• Expiry date: Feb 19, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/565
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical preparations containing selected steroid compounds and methods of treating estrogen deficiency in the central nervous system (CNS) without influencing other organs or systems are described. These steroids have selective neurotropic estrogen-like transcription action in contrast to the systemically acting natural and synthetic estrogen compounds, such as 17.alpha.-estradiol. The selected steroids surprisingly have a selective influence on the transcription estrogen-dependent gene in the CNS and cause changes of physiological parameters as well as CNS-specific transcription effects in the dosages used with no biological effects in reproductive system tissues. They have CNS specific transcription effects at those dosages at which neither 17 .beta.-estradiol nor 17.alpha.-estradiol had any action and the transcription estrogen-dependent gene in the CNS is not influenced by secondarily formed 17.beta.-estradiol.