Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
US6245758A · kind A · utility
Inventors
Key dates
| Filing date | Sep 9, 1996 |
| Grant date | Jun 12, 2001 |
| Priority date | — |
| Expiry date | Sep 9, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/555
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method for the treatment of diseases by the decomposition of peroxynitrite, preferably decomposition to benign products, comprising the use of a complex which is a selected ligand structure providing a complexed metal such as Mn, Fe, Ni and V transition metals. The method of use, as well as novel pharmaceutical compositions therefor, are for the treatment of diseases advantageously affected by decomposition of peroxynitrite ed at a rate over the natural background rate of decay of peroxynitrite in humans suffering from the disease which comprises administration of an amount of a complex, in dosage unit form, which is effective for such acceleration of the decomposition of peroxynitrite .
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.