.beta.-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6245764A · kind A · utility
26Cited by
3References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 20, 1998 |
| Grant date | Jun 12, 2001 |
| Priority date | — |
| Expiry date | Jan 20, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/1024
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are disclosed .beta.-sheet mimetics and methods relating to the same for imparting or stabilizing the .beta.-sheet structure of a peptide, protein or molecule. In one aspect, .beta.-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the .beta.-sheet mimetic is a thrombin inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.