Formulations and methods for treatment of mucosal associated conditions with an immune response modifier

US6245776A · kind A · utility

Assignee

• 3M INNOVATIVE PROPERTIES COMPANY · US

Inventors

• Raymond D. Skwierczynski · Oakdale, US
• Kenneth R. Phares · Chapel Hill, US
• Richard L. Miller · Dix Hills, US
• Zheng Li · Quaker Hill, US
• Michael J. Jozwiakowski · Stillwater, US
• Terri F. Busch · Windom, US

Key dates

• Filing date: Jan 7, 2000
• Grant date: Jun 12, 2001
• Expiry date: Jan 7, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Immune response modifier (IRM) compounds--imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo- and oxazolo-quinolinamines and pyridinamines, imidazonaphthyridine and tetrahydroimidazonaphthyridine amines--are useful for the treatment of conditions at and below the mucosal surfaces by administering a therapeutically effective amount of such compounds to the mucosal surface. Novel pharmaceutical formulations are provided. In one embodiment, the pharmaceutical formulations are advantageous for treatment of cervical conditions such as cervical dysplasias including cervical intraepithelial neoplasias.