Dissolution of triprolidine hydrochloride
US6245785A · kind A · utility
0Cited by
2References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 30, 1998 |
| Grant date | Jun 12, 2001 |
| Priority date | — |
| Expiry date | Nov 30, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to pharmaceutical compositions containing triprolidine and an ionic additive that improves the measured availability of the triprolidine in the tablet, as indicated by standard USP assay for triprolidine in pharmaceutical compositions. The invention also provides a process for producing compositions having improved triprolidine availability and a process for improving the performance of a pharmaceutical composition in a dissolution assay measuring triprolidine availability. The ionic additive can be, for example, an alkali metal salt, such as sodium chloride or potassium chloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.