Peptides and peptidomimetics with structural similarity to human P53 that activate P53 function

US6245886A · kind A · utility

Assignees

• BAYER HEALTHCARE LLC · DE
• The Wistar Institute · US

Inventors

• Thanos Halazonetis · Philadelphia, US
• Wolfgang Hartwig · Wuppertal, DE

Key dates

• Filing date: Dec 4, 1997
• Grant date: Jun 12, 2001
• Expiry date: Dec 4, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/82
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and to select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.