Selective hydrolysis of acetals or ketals in the presence of phthalides

US6245945A · kind A · utility

Assignee

• BASF SE

Inventors

• Andreas Weiper-Idelmann · Waldsee, DE
• Heinz Hannebaum · Ludwigshafen, DE
• Hermann Putter · Neustadt, DE

Key dates

• Filing date: Aug 25, 2000
• Grant date: Jun 12, 2001
• Expiry date: Aug 25, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/88
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the selective hydrolysis of acetals in the presence of phthalides comprises reacting a mixture (M) comprising PA1 a) a phthalide of the formula (I) ##STR1## where: PA1 R.sup.1,R.sup.2,R.sup.3 and R.sup.4 : are independently hydrogen, C.sub.1 -C.sub.4 -alkyl or halogen, and PA1 b) an acetal or ketal of the formula (II) ##STR2## where: PA1 R.sup.5 and R.sup.6 : are independently C.sub.1 -C.sub.6 -alkyl, C.sub.6 -C.sub.10 -aryl or together ethylene, and PA1 R.sup.7 and R.sup.8 : are independently C.sub.1 -C.sub.6 -alkyl, or one radical is a hydrogen and the other is a phenyl radical where from 1 to 3 hydrogen atoms of the phenyl radical may be replaced by C.sub.1 -C.sub.6 -alkyl radicals or C.sub.1 -C.sub.4 -alkoxy radicals, or R.sup.7 and R.sup.8 are together C.sub.3 -C.sub.6 -alkanediyl, and a hydrogen atom may be replaced by a hydroxyl group, at from 10 to 200.degree. C. in the presence of from 1 to 10 mol of water, based on the amount of acetal or ketal of the formula (II), to hydrolyze the acetal or ketal of the formula (II) to the corresponding aldehyde or ketone.